INGREDIENTSMelatonin (1 mg), pyridoxine (vitamin B6) 0.7 mg, microcrystalline cellulose (stabilizer), magnesium salts of fatty acids (stabilizer), silicon oxide (anti-caking agent), hydroxypropyl methylcellulose (stabilizer), titanium dioxide (colorant), indigo carmine (colorant).Presentation 1.95Melatonin (1.95 mg), pyridoxine (vitamin B6) 0.7 mg, microcrystalline cellulose (stabilizer), silicon oxide (anti-caking agent), magnesium stearate (stabilizer), hydroxypropyl methylcellulose (stabilizer), colors: titanium dioxide and indigo carmine.HOW TO USE1 tablet before going to bed. It is recommended to take the tablet at the same time.OTHERAccording to the Report of the Scientific Committee of the Spanish Agency for Consumer Affairs, Food Safety and Nutrition (AECOSAN) on the conditions of use of certain substances to be used in food supplements: MelatoninAECOSAN has proposed a maximum daily amount for melatonin of 1 mg. This proposal is based on the authorization of two health claims, in relation to melatonin contributing to• alleviating the subjective sensation of jet lag:It can only be used with foods that contain a minimum of 0.5 mg of melatonin per quantified portion. For a product to bear this claim, the consumer must be informed that the beneficial effect is obtained with a minimum intake of 0.5 mg to be taken shortly before going to bed on the first day of travel and a few days after arrival at the destination (EU, 2012). Melatonin contributes to reducing the time taken to fall asleep. Can only be used with foods containing 1 mg of melatonin per quantified portion. In order for a product to bear this claim, the consumer must be informed that the beneficial effect is obtained with an intake of 1 mg of melatonin shortly before going to sleep (EU, 2012). Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone produced by the pineal gland of mammals and other organs, especially the enterochromaffin cells of the gastrointestinal tract and the retina (Hardeland et al., 1993) (Huether, 1993), whose main physiological function is the regulation or control of circadian and seasonal rhythms (Armstrong et al., 1986). It was discovered in the 1950s (Lerner et al., 1958, 1959). In recent years it has been shown that melatonin also has numerous additional functions; it is produced and acts on numerous tissues or cells that express melatonin receptors, at much lower levels (Hardeland, 2009). Melatonin receptors MT1 and MT2 (membrane receptors) have been detected in numerous tissues of the CNS (Central Nervous System), in peripheral organs such as the gastrointestinal tract, liver, lung, skin, adrenal gland, gonads, male organs, breast tissue, kidney, heart, blood vessels, adipose tissue, neutrophils, lymphocytes and lymphoid tissue (Ishii et al., 2009). Both receptors involve signaling through cAMP inhibition, protein kinase A activity, effects on phospholipase A2 and C, and effects on potassium and calcium channels (Mathes, 2010). A third receptor, MT3, has also been described as an enzyme identified as quinone reductase 2. Deficiencies in melatonin production or in receptor expression or decreases in melatonin levels (such as those that occur with age) lead to numerous dysfunctions. In these cases, with insufficient melatonin levels or poor melatoninergic signaling, numerous pathophysiological alterations can occur, reflecting the pleiotropy of the molecule. Thus, for example, a decrease in nocturnal melatonin levels has been repeatedly observed in patients with neurodegenerative disorders and sleep disturbances (Uchida et al., 1996). USE IN PATIENTS WITH FOOD INTOLERANCE This product can be taken by a person with celiac disease, allergy/intolerance to eggs, or intolerance to milk.