ACTION AND MECHANISM

Broad-spectrum antiseptic, antibacterial (bactericidal), antifungal (fungicidal), antiviral, antiprotozoal, sporicidal. It is a molecular complex of iodine with povidone. The complex, as such, has no activity until iodine, which is truly responsible for the antiseptic action, is released. Dilution increases the iodine release process. Iodine acts through oxidation-reduction reactions, altering many biologically important molecules, such as glucose, starch, glycols, lipids, proteins, etc. In this process, iodine is transformed into iodide, which is biologically inactive. Iodine has a very broad antimicrobial spectrum. The emergence of resistant microbial strains has not been detected.

CONTRAINDICATIONS

- [IODIDE ALLERGY].- Do not use compounds containing mercury derivatives.- Iodine loses activity in the presence of organic matter.

PREGNANCY

In a recent study, use in low-birth-weight infants caused neonatal hypothyroidism. Women treated with povidone-iodine douches for 14 days did not develop hypothyroidism. However, there is a significant increase in serum and urinary iodine excretion. Caution should be exercised during pregnancy and breastfeeding.

INDICATIONS

- Dermal solution, ointment, gel: Antiseptic and disinfectant for general use on skin, small wounds and superficial cuts, minor [BURNS], [BEDSORES]. In the hospital setting as an antiseptic for the operating field, puncture sites, wounds, burns and surgical material. - Scrub: disinfectant wash for hands and skin. - Shampoo: disinfectant wash for hairy areas of the body.

POSOLOGY

Depending on the indication, it can be used neat or diluted.- Dermal solution: After washing and drying, apply directly to the affected area.- Gel: After washing and drying, apply directly to the affected area 1-3 times a day. After application, it is advisable to cover the area with gauze.- Scrub: Use a small amount of product, rubbing for 2-5 minutes until a lather forms. Rinse thoroughly with water or a sterile gauze soaked in water.- Shampoo: Apply directly to the affected area. On the scalp, perform 2 successive applications, after rinsing the head with warm water. For the second application, rub until a lather forms and leave on for about 5 minutes. Rinse thoroughly with water.

PRECAUTIONS

- Thyroid function tests should be performed in case of prolonged treatment.- Avoid contact with eyes, ears and mucous membranes.- Organic matter (proteins, blood, etc.) decreases its activity.- It is inactivated by sodium thiosulfate: possible antidote in case of poisoning.

ADVERSE REACTIONS

Rarely, local irritation and hypersensitivity reactions may occur. Application of povidone-iodine to extensive wounds may produce adverse systemic effects such as metabolic acidosis, hypernatremia, and impaired renal function.

OVERDOSE

- Symptoms: Local: Skin irritation. Treatment: Local: Wash the injured area with plenty of water and apply anti-inflammatory drugs, including corticosteroids, topically. Accidental ingestion of large amounts: Symptomatic and supportive treatment, monitoring acid-base balance and kidney and thyroid function.

COMPOSITION

POVIDONE IODINE (TOPICAL): 100 MILLIGRAMS